Transforming growth factor-β (TGF-β) is a potent regulatory cytokine with diverse effects on
hemopoietic cells. The pivotal function of TGF-β in the immune system is to maintain …

Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term ‘lncRNAs’ encompasses RNA polymerase I (Pol I), Pol II …

… Figure 8 (A) SAXS traces of mesoporous silica LP-FDU-12 samples (S-x-y represents the
FDU-12 sample synthesized at x C, followed by hydrothermal treatment at y C. (B) The …

The naturally occurring regulatory T cell (T r ) is the pivotal cell type that maintains self-tolerance
and exerts active immune suppression. The development and function of T r cells is …

To the Editor—Rapid advances in DNA-sequencing and bioinformatics technologies in the
past two decades have substantially improved understanding of the microbial world. This …

Background No specific antiviral drug has been proven effective for treatment of patients
with severe coronavirus disease 2019 (COVID-19). Remdesivir (GS-5734), a nucleoside …

We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising
33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we …

Long intergenic noncoding RNAs (lincRNAs) regulate chromatin states and epigenetic
inheritance. Here, we show that the lincRNA HOTAIR serves as a scaffold for at least two distinct …

Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and
cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-…

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic
annotation data along with multi-platform molecular profiles of more than 11,000 human tumors …