[HTML][HTML] SDH mutations in cancer

C Bardella, PJ Pollard, I Tomlinson - Biochimica et Biophysica Acta (BBA) …, 2011 - Elsevier
… vitro demonstrated that the p.Gly78Arg mutation destabilized … a second family carrying the
p.Gly78Arg mutation in SDHAF2. … the two families, suggesting that p.Gly78Arg mutation has no …

[HTML][HTML] Oncometabolites: linking altered metabolism with cancer

M Yang, T Soga, PJ Pollard - The Journal of clinical …, 2013 - Am Soc Clin Investig
The discovery of cancer-associated mutations in genes encoding key metabolic enzymes
has provided a direct link between altered metabolism and cancer. Advances in mass …

Judgements about victims and attackers in depicted rapes: A review

P Pollard - British Journal of Social Psychology, 1992 - Wiley Online Library
This paper reviews the effects on subjects' judgements of a variety of factors that have been
included in experimental depictions of rape. The focus is on attribution of responsibility or …

Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations

PJ Pollard, JJ Briere, NA Alam, J Barwell… - Human molecular …, 2005 - academic.oup.com
… FH-deficient patients (P=0.011, Wilcoxon test and P=0.05, t-test). No other significant differences
between the two groups of patients exist (P>0.05, Wilcoxon and t-tests) data not shown). …

[HTML][HTML] Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

…, T Schmidt, B Jonckx, YM Tian, AA Lanahan, P Pollard… - Cell, 2009 - cell.com
A key function of blood vessels, to supply oxygen, is impaired in tumors because of abnormalities
in their endothelial lining. PHD proteins serve as oxygen sensors and may regulate …

On the conflict between logic and belief in syllogistic reasoning

JSBT Evans, JL Barston, P Pollard - Memory & cognition, 1983 - Springer
… ; p <.01, onetailed sign test). There was also a tendency to accept more valid than invalid
arguments overall (p <.02, one-tailed) and a significant Belief by Validity interaction (p <.05). …

[HTML][HTML] Genome-wide association of hypoxia-inducible factor (HIF)-1α and HIF-2α DNA binding with expression profiling of hypoxia-inducible transcripts

DR Mole, C Blancher, RR Copley, PJ Pollard… - Journal of biological …, 2009 - ASBMB
Hypoxia-inducible factor (HIF) controls an extensive range of adaptive responses to hypoxia.
To better understand this transcriptional cascade we performed genome-wide chromatin …

[PDF][PDF] Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

…, BM Kessler, M El-Bahrawy, PJ Ratcliffe, PJ Pollard - Cancer cell, 2011 - cell.com
… and Hif-1a (Figure 4B) and confirmed that Fh1 is significantly reduced (p < 0.05) in the Fh1
… Gsta1, Hmox1, and Nqo1 are significantly reduced by depletion of Nrf2 (p < 0.02), but not by …

An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a …

…, P Komminoth, K Pacak, WCJ Hop, PJ Pollard… - The lancet …, 2009 - thelancet.com
Background Phaeochromocytomas and paragangliomas are neuro-endocrine tumours that
occur sporadically and in several hereditary tumour syndromes, including the …

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

…, A Hedley, G Kalna, IPM Tomlinson, PJ Pollard… - Nature, 2011 - nature.com
… Multiple test corrections were performed for all calculated P-values. Step-up P-value, a P-value
that controls the false discovery rate, and the fold change values were used for further …