User profiles for M. DePalma

Michele De Palma

Associate Professor at EPFL - Switzerland
Verified email at epfl.ch
Cited by 21014

[PDF][PDF] Macrophage regulation of tumor responses to anticancer therapies

M De Palma, CE Lewis - Cancer cell, 2013 - cell.com
Tumor-associated macrophages (TAMs) promote key processes in tumor progression, like
angiogenesis, immunosuppression, invasion, and metastasis. Increasing studies have also …

An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy

…, JL Baisden, S Bess, CH Cho, MJ DePalma… - The Spine Journal, 2014 - Elsevier
DePalma MD h , Paul Dougherty II DC i , Robert Fernand MD j , Gary Ghiselli MD k , Amgad
S. Hanna MD l , Tim Lamer MD m , Anthony J. Lisi DC n , Daniel J. Mazanec MD o , Richard J…

The interplay between macrophages and angiogenesis in development, tissue injury and regeneration

S Nucera, D Biziato, M De Palma - The International journal of …, 2011 - infoscience.epfl.ch
De Palma and co-workers showed that the genetic depletion of TEMs was sufficient to … in
various subcutaneous tumor models (De Palma et al., 2003; De Palma et al., 2005). Moreover, …

What is the source of chronic low back pain and does age play a role?

MJ DePalma, JM Ketchum, T Saullo - Pain medicine, 2011 - academic.oup.com
Objective. The objective of this study was to estimate the prevalence, mean age, and
association of prevalence and age of lumbar internal disc disruption (IDD), facet joint pain (FJP), …

[PDF][PDF] Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells

…, LS Politi, B Gentner, JL Brown, L Naldini, M De Palma - Cancer cell, 2011 - cell.com
Tumor-infiltrating myeloid cells convey proangiogenic programs that counteract the efficacy
of antiangiogenic therapy. Here, we show that blocking angiopoietin-2 (ANG2), a TIE2 ligand …

A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood “resident” monocytes, and embryonic macrophages suggests common …

…, C Di Serio, L Naldini, M De Palma - Blood, The Journal …, 2009 - ashpublications.org
We previously showed that Tie2-expressing monocytes (TEMs) have nonredundant
proangiogenic activity in tumors. Here, we compared the gene expression profile of tumor-infiltrating …

[PDF][PDF] Tumor-targeted interferon-α delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis

M De Palma, R Mazzieri, LS Politi, F Pucci, E Zonari… - Cancer cell, 2008 - cell.com
The use of type I interferons (IFNs) in cancer therapy has been limited by ineffective dosing
and significant toxicity. Here, we exploited the tumor-homing ability of proangiogenic Tie2-…

[HTML][HTML] TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice

…, C Di Serio, L Naldini, M De Palma… - The Journal of …, 2011 - Am Soc Clin Investig
Vascular-disrupting agents (VDAs) such as combretastatin A4 phosphate (CA4P) selectively
disrupt blood vessels in tumors and induce tumor necrosis. However, tumors rapidly …

Etiology of chronic low back pain in patients having undergone lumbar fusion

MJ DePalma, JM Ketchum, TR Saullo - Pain medicine, 2011 - academic.oup.com
Objective. To estimate the prevalence of lumbar internal disc disruption, zygapohyseal joint
pain, sacroiliac joint pain, and soft tissue irritation by fusion hardware in post-fusion low back …

Toward a theory of adaptive transfer: Expanding disciplinary discussions of “transfer” in second-language writing and composition studies

MJ DePalma, JM Ringer - Journal of Second Language Writing, 2011 - Elsevier
In this paper, we argue that discussions of transfer in L2 writing and composition studies have
focused primarily on the reuse of past learning and thus have not adequately accounted …