User profiles for M. Darnell
Max Darnell, PhDPostdoctoral Fellow, Seelig Lab, University of Washington Verified email at uw.edu Cited by 5048 |
Hydrogels with tunable stress relaxation regulate stem cell fate and activity
Natural extracellular matrices (ECMs) are viscoelastic and exhibit stress relaxation. However,
hydrogels used as synthetic ECMs for three-dimensional (3D) culture are typically elastic. …
hydrogels used as synthetic ECMs for three-dimensional (3D) culture are typically elastic. …
Leveraging advances in biology to design biomaterials
Biomaterials have dramatically increased in functionality and complexity, allowing unprecedented
control over the cells that interact with them. From these engineering advances arises …
control over the cells that interact with them. From these engineering advances arises …
Inactivation of the coronavirus that induces severe acute respiratory syndrome, SARS-CoV
MER Darnell, K Subbarao, SM Feinstone… - Journal of virological …, 2004 - Elsevier
Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by a novel
coronavirus termed SARS-CoV. Due to the severity of this disease, the World Health …
coronavirus termed SARS-CoV. Due to the severity of this disease, the World Health …
[HTML][HTML] Substrate stress relaxation regulates cell spreading
Studies of cellular mechanotransduction have converged upon the idea that cells sense
extracellular matrix (ECM) elasticity by gauging resistance to the traction forces they exert on the …
extracellular matrix (ECM) elasticity by gauging resistance to the traction forces they exert on the …
Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation
The effectiveness of stem cell therapies has been hampered by cell death and limited
control over fate. These problems can be partially circumvented by using macroporous …
control over fate. These problems can be partially circumvented by using macroporous …
Performance and biocompatibility of extremely tough alginate/polyacrylamide hydrogels
… As a recently described interpenetrating network (IPN) of alginate and polyacrylamide
demonstrated a fracture toughness of ∼9000 J/m 2 , we sought to explore the biocompatibility and …
demonstrated a fracture toughness of ∼9000 J/m 2 , we sought to explore the biocompatibility and …
Matrix viscoelasticity controls spatiotemporal tissue organization
Biomolecular and physical cues of the extracellular matrix environment regulate collective cell
dynamics and tissue patterning. Nonetheless, how the viscoelastic properties of the matrix …
dynamics and tissue patterning. Nonetheless, how the viscoelastic properties of the matrix …
The CLEC-2–podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture
In lymph nodes, fibroblastic reticular cells (FRCs) form a collagen-based reticular network
that supports migratory dendritic cells (DCs) and T cells and transports lymph. A hallmark of …
that supports migratory dendritic cells (DCs) and T cells and transports lymph. A hallmark of …
Metabolism of xenobiotic carboxylic acids: focus on coenzyme A conjugation, reactivity, and interference with lipid metabolism
M Darnell, L Weidolf - Chemical research in toxicology, 2013 - ACS Publications
While xenobiotic carboxylic acids (XCAs) have been studied extensively with respect to
their enzymatic conversion to potentially reactive acyl glucuronides with implications to drug …
their enzymatic conversion to potentially reactive acyl glucuronides with implications to drug …
Evaluation of inactivation methods for severe acute respiratory syndrome coronavirus in noncellular blood products
MER Darnell, DR Taylor - Transfusion, 2006 - Wiley Online Library
BACKGROUND: Severe acute respiratory syndrome coronavirus (SARS‐CoV) has been
detected in the blood of infected individuals, which may have the potential to contaminate …
detected in the blood of infected individuals, which may have the potential to contaminate …