Retrotransposons are mobile genetic elements that use a germline ‘copy-and-paste’ mechanism
to spread throughout metazoan genomes 1 . At least 50 per cent of the human genome …

LINE-1 (L1) retrotransposons are mobile genetic elements comprising ∼17% of the human
genome. New L1 insertions can profoundly alter gene function and cause disease, though …

Somatic LINE-1 (L1) retrotransposition during neurogenesis is a potential source of genotypic
variation among neurons. As a neurogenic niche, the hippocampus supports pronounced …

… , 1% SDS, 1 Mm NaCl, 10 μg/mL Proteinase K). Following digest, DNA was purified using
phenol-… Goodier, and Prabhat K. Mandal for their great insights into the project and for their …

Chromosome segregation relies on the dynamic properties of spindle microtubules (MTs).
Poleward MT flux contributes to spindle dynamics through the disassembly of MT minus ends …

Accelerating cures for children with cancer remains an immediate challenge as a result of
extensive oncogenic heterogeneity between and within histologies, distinct molecular …

… We found no de novo LTR retrotransposon insertions, despite observing profound upregulation
of HERV-K group HML-2 transcription in hiPSCs and hESCs (Supplementary Methods; …

Groundwater forms the basis of water supplies across much of Africa and its development is
rising as demand for secure water increases. Recharge rates are a key component for …

We have produced Csf1r-deficient rats by homologous recombination in embryonic stem
cells. Consistent with the role of Csf1r in macrophage differentiation, there was a loss of …

Background In the acute medical care hospital setting, nursing the sick and dying is both
physically and emotionally demanding, making acute medical care hospital nurses more …