In many areas of animal behaviour research, improvements in our ability to collect large and
detailed data sets are outstripping our ability to analyse them. These diverse, complex and …

Degeneration of basal forebrain cholinergic neurons (BFCNs) contributes to cognitive
dysfunction in Alzheimer's disease (AD) and Down's syndrome (DS). We used Ts65Dn and …

… receptors at pH 7.4 remains bound at pH 5.5 (J. Zhou and W. Mobley, unpublished observations),
ie, … TrkA in intracellular organelles (J. Zhou and W. Mobley, unpublished observations). …

Target-derived NGF promotes the phenotypic maintenance of mature dorsal root ganglion (DRG)
nociceptive neurons. Here, we provide in vivo and in vitro evidence for the presence …

The target-derived neurotrophic factor "nerve growth factor" (NGF) signals through TrkA to
promote the survival, differentiation, and maintenance of neurons. How the NGF signal in axon …

… Recent data indicate that NGF actions in inducing trk gene expression are more rapid
under low serum conditions (J. Zhou and W. Mobley, … gift of J. Mallet). This probe recognizes …

Emerging evidence suggests that the p75 neurotrophin receptor (p75 NTR ) mediates cell
death; however, it is not known whether p75 NTR negatively regulates other neuronal …

… (J and R) Erk1/2 were found in CCVs. There was no increase in total Erk1/2 in CCVs
following NGF treatment. (B and R) However, the same blot reprobed with anti-p-Erk1/2 (ie, Erk1 …

Down syndrome (trisomy 21) is the most common cause of mental retardation in children and
leads to marked deficits in contextual learning and memory. In rodents, these tasks require …

Background There are over 200 million reported cases of malaria each year, and most
children living in endemic areas will experience multiple episodes of clinical disease before …