The primary mechanism of attenuation of bacillus Calmette–Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue
…, D Eisenberg, RG Russell, SC Derrick… - Proceedings of the …, 2003 - National Acad Sciences
Tuberculosis remains a leading cause of death worldwide, despite the availability of effective
chemotherapy and a vaccine. Bacillus Calmette–Guérin (BCG), the tuberculosis vaccine, is …
chemotherapy and a vaccine. Bacillus Calmette–Guérin (BCG), the tuberculosis vaccine, is …
Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk
… kits according to the manufacturer’s directions (Oxford Biomedical Research, Oxford, MI). …
(Qiagen), according to the manufacturer’s protocol. Total RNA from lung tissue was isolated by …
(Qiagen), according to the manufacturer’s protocol. Total RNA from lung tissue was isolated by …
Fissure seal or fluoride varnish? A randomized trial of relative effectiveness
…, N Aawar, L Angel, S Derrick… - Journal of dental …, 2017 - journals.sagepub.com
Fissure sealant (FS) and fluoride varnish (FV) are effective in preventing dental caries when
compared with a no-treatment control. However, the relative clinical effectiveness of these …
compared with a no-treatment control. However, the relative clinical effectiveness of these …
A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis
…, X Wang, B Chen, RG Russell, S Derrick… - Nature medicine, 2002 - nature.com
With the advent of HIV and the widespread emergence of drug-resistant strains of Mycobacterium
tuberculosis, newer control strategies in the form of a better vaccine could decrease …
tuberculosis, newer control strategies in the form of a better vaccine could decrease …
[HTML][HTML] Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis
…, M Braunstein, IM Orme, SC Derrick… - The Journal of …, 2007 - Am Soc Clin Investig
The inhibition of apoptosis of infected host cells is a well-known but poorly understood
function of pathogenic mycobacteria. We show that inactivation of the secA2 gene in …
function of pathogenic mycobacteria. We show that inactivation of the secA2 gene in …
The ESAT6 protein of Mycobacterium tuberculosis induces apoptosis of macrophages by activating caspase expression
SC Derrick, SL Morris - Cellular microbiology, 2007 - Wiley Online Library
… Inhibitors of MyD88, an adaptor protein known to be involved in proximal TLR signalling,
did not prevent the induction of apoptosis by ESAT6 (S. Derrick, unpubl. results). The …
did not prevent the induction of apoptosis by ESAT6 (S. Derrick, unpubl. results). The …
[HTML][HTML] Effects of dietary red raspberry consumption on pre-diabetes and type 2 diabetes mellitus parameters
SA Derrick, AS Kristo, SK Reaves… - International Journal of …, 2021 - mdpi.com
Type 2 diabetes mellitus (T2DM) is a chronic metabolic condition characterized by glucose
clearance abnormalities and insufficient insulin response. Left uncontrolled, T2DM can result …
clearance abnormalities and insufficient insulin response. Left uncontrolled, T2DM can result …
Mycobacterium tuberculosis ΔRD1 ΔpanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against …
VK Sambandamurthy, SC Derrick, T Hsu, B Chen… - Vaccine, 2006 - Elsevier
… We have recently shown that the mc 2 6030-induced protection of CD4 −/− mice against
a tuberculous challenge cannot be ablated by antibody depletion of CD8 T cells (S. Derrick, …
a tuberculous challenge cannot be ablated by antibody depletion of CD8 T cells (S. Derrick, …
Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection …
…, J Fulkerson, C Scanga, A Grover, SC Derrick, S Morris… - Vaccine, 2009 - Elsevier
… Current efforts are focused on making better BCG priming vaccines designed to induce a
comprehensive and balanced immunity followed by booster(s) targeting a specific set of …
comprehensive and balanced immunity followed by booster(s) targeting a specific set of …
Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis
VK Sambandamurthy, SC Derrick… - Infection and …, 2005 - Am Soc Microbiol
We report the safety and immunogenicity of a double lysine and pantothenate auxotroph of
Mycobacterium tuberculosis in mice. The ΔlysA ΔpanCD mutant is completely attenuated in …
Mycobacterium tuberculosis in mice. The ΔlysA ΔpanCD mutant is completely attenuated in …