Human umbilical vein endothelial cells (HUVECs) have played a major role as a model system
for the study of the regulation of endothelial cell function and the role of the endothelium …

Subunits ofguanine nucleotide regulatory proteins purified from bovine cerebral cortex were
used to perfuse the intracellular surface of excised patches of chick embryonic atrial cells. …

Angiogenesis is implicated in the pathogenesis of cancer, rheumatoid arthritis, and
atherosclerosis and in the treatment of coronary artery and peripheral vascular disease. Here, …

Objective— Atherosclerosis encompasses a conspicuously maladaptive inflammatory
response that might involve innate immunity. Here, we compared the role of Toll-like receptor 4 (…

Many genetic risk factors for Parkinson’s disease have lipid-related functions and lipid-modulating
drugs such as statins may be protective against Parkinson’s disease. Moreover, the …

Cyclin F, encoded by CCNF, is the substrate recognition component of the Skp1-Cul1-F-box
E3 ubiquitin ligase complex, SCF cyclin F . E3 ubiquitin ligases play a key role in ubiquitin-…

Background Pathological forms of TAR DNA-binding protein 43 (TDP-43) are present in motor
neurons of almost all amyotrophic lateral sclerosis (ALS) patients, and mutations in TDP-…

Objective— Abdominal aortic aneurysm (AAA) is a life-threatening disease affecting almost
10% of the population over age 65. Generation of AAAs by infusion of angiotensin (Ang) II in …

Genetic alterations in the LRRK2 gene, encoding leucine-rich repeat kinase 2, are a common
risk factor for Parkinson’s disease. How LRRK2 alterations lead to cell pathology is an …

Abdominal Aortic Aneurysm (AAA) is a major cause of mortality and morbidity in men over 65
years of age. Male apolipoprotein E knockout (ApoE −/− ) mice infused with angiotensin II (…